WELLINGTON Laboratories continues to support and participate in scientific research and development. Not only does this research increase the knowledge of our staff, it allows them to work with other experts in the field and help us improve our products and technical support. As can be seen, the synthetic expertise of Wellington Laboratories is supported by strong analytical capabilities. Our published research represents a minor portion of the day-to-day research carried out at WELLINGTON.
Such research was the impetus for the formation of WELLINGTON and will continue to be the foundation of our company and the strength of our people. The company's commitment is to continue its support and participation in scientific research.
The staff at WELLINGTON have well over 200 publications and examples of some of these are given below.
| P. Liu, J.D. Goddard, G. Arsenault, J. Gu, A. McAlees, R. McCrindle, V. Robertson, "Theoretical studies of the conformations and 19F NMR spectra of linear and a branched perfluorooctanesulfonamide (PFOSAmide)", Chemosphere., 69, 1213-1220, (2007). |
| G. Arsenault, A. Konstantinov, C. Marvin, G. MacInnis, A. McAlees, R. McCrindle, N. Riddell, G. Tomy, B. Yeo, "Synthesis of the two minor isomers, delta- and epsilon-1,2,5,6,9,10-hexabromocyclododecane, present in commercial hexabromocyclododecane", Chemosphere., 68, 887-892, (2007). |
| G. Arsenault, B. Chittim, A. McAlees, R. McCrindle, D. Potter, C. Tashiro and B. Yeo, "Mass spectral studies of native and mass-labeled perfluorooctanesulfonamides", Rapid Commun. Mass Spectrom., 21, 929-936, (2007). |
| G. Arsenault, B. Chittim, A. McAlees, R. McCrindle, "Nuclear magnetic resonance spectral characterization and semi-empirical calculations of conformations of alpha- and gamma-1,2,5,6,9,10-hexabromocyclododecane", Chemosphere, 67, 1684-1694, (2007). |
| H.M. Stapleton, B. Brazil, R.D. Holbrook, C.L. Mitchelmore, R. Benedict, A. Konstantinov, D. Potter, "In Vivo and In Vitro Debromination of Decabromodiphenyl Ether (BDE209) by Juvenile Rainbow Trout and Common Carp", Environ. Sci. Technol, 40(15), 4653-4658, (2006). |
| S. Khan, A. Konstantinov, B. Chittim, A. McAlees, B. Yeo, S. Safe, "Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes", Toxicology in Vitro, 20(7), 1234-1237, (2006). |
| A. Konstantinov, G. Arsenault, B. Chittim, K. Mac Pherson, A. McAlees, R.. McCrindle, D. Potter, E.J. Reiner, C. Tashiro and B.R. Yeo, "Characterization of Mass-Labeled [13C14] - Decabromodiphenylethane and its use as a Surrogate Standard in the Analysis of Sewage Sludge Samples", Submitted to Chemosphere for publication (2005). |
| P.M.L. Bonin, P. Edwards, D. Bejan, C.C. Lo, N.J. Bunce and A.D. Konstantinov, "Catalytic and Electrocatalytic hydrognolysis of brominated diphenyl ethers", Chemosphere, 58, 961 (2005). |
| D.R.Boverhof, L.D.Burgoon, C.Tashiro, B.Chittim, J.R.Harkema, D.B.Jump, T.R.Zacharewski, “Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity”, Toxicological Sciences, 85, 1048-1063, (2005). |
| G.Arsenault, B.Chittim, D.Ellis, T.Halldorson, S.Mabury, A.McAlees, R.McCrindle, N.Stock, G.Tomy, B.Yeo, “Nuclear magnetic resonance and LC/MS characterization of native and new mass-labeled fluorinated telomer alcohols, acids and unsaturated acids”, Organohalogen Compounds, 66, 3965-3972 (2004). |
| R.McCrindle, B.Chittim, A.Konstantinov, T.Kolic, A.McAlees, K.MacPherson, E.Reiner, D.Potter, C.Tashiro, B.Yeo, “Native and mass labeled [13C14]-decabromodiphenylethane (DBDPE): characterization and use in detemination of DBDPE in sewage sludge”, Organohalogen Compounds, 66, 3744-3750, (2004). |
| G.Arsenault, B.Chittim, A.McAlees, R.McCrindle, “NMR spectral characterization and semi-emperical calculations for the conformations of alpha- and gamma-1,2,5,6,9,10-hexabromocyclododecane”, Organohalogen Compounds, 66, 3678-3684, (2004). |
| G.Arsenault, B.Chittim, T.Halldorson, A.Konstantinov, A.McAlees, R.McCrindle, G.Tomy, B.Yeo, “Synthesis of carbon-13 (13C12) and deuterated (D18) gamma-hexabromocyclododecane and their use as surrogate standards in LC/MS and GC/MS analysis”, Organohalogen Compounds, 61 267-270, (2003). |
| D.Desaulniers, K.Leingartner, J.Russo, G.Perkins, B.G.Chittim, M.C.Archer, M.Wade, J.Yang, “Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p,p'-DDE, on methylnitrosourea-induced mammary tumor development in the rat”, Environmental Health Perspectives, 109, 739-747, (2001). |
| G.Chen, A.Konstantinov, B.G.Chittim, E.M.Joyce, N.C.Bols, N.J.Bunce, “Synthesis of Polybrominated Diphenyl Ethers and Their Capacity to Induce CYP1A by the Ah Receptor Mediated Pathway”, Environmental Science and Technology, 35, 3749-3756, (2001). |
| M.R.Fielden, R.G.Halgren, C.Tashiro, B.Yeo, B.Chittim, K.Chou, T.R.Zacharewski, “Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice”, Reproductive Toxicology, 15, 281-292, (2001). |
| S.Selliah, S.Cussion, E.J.Reiner, K.A.MacPherson, T.M.Kolic, D.Toner, B.Chittim, “A reference material for routine performance monitoring of methods measuring dioxin-like compounds in solid matrices”, Organohalogen Compounds , 45 156-159, (2000). |
| C.D.Sandau, I.A.Meerts, Ilonka, R.J.Letcher, A. McAlees, B. Chittim, A.Brouwer, R.J.Norstrom, “Identification of 4-Hydroxyheptachlorostyrene in Polar Bear Plasma and Its Binding Affinity to Transthyretin: A Metabolite of Octachlorostyrene?”, Environmental Science and Technology, 34, 3871-3877, (2000). |
| A.D. Konstantinov, A.M. Johnston, B.J. Cox, J.R. Petrulis, M.T. Orzechowski, N.J. Bunce, C. Tashiro and B. Chittim, "Photolytic Method for Destruction of Dioxins in Liquid Laboratory Waste and Identification of the Photoproducts from 2,3,7,8-TCDD", Environ. Sci. Technol., 34, 143-148 (2000). |
| C.Tashiro, D.W.Potter, B.R.Yeo, B.J.Sharrat, C.J.Harrison, F.J.Campbell, B.G.Chittim, E.Reiner, K.MacPherson, T.Kolic, “Congener specific PCB analysis by HRGC/HRMS. Reference materials”, Organohalogen Compounds, 31 56-60, (1997). |
| M.R. Fielden, I. Chen, B. Chittim, S.H. Safe and T. Zacharewski, "Examination of the Estrogenicity of 2,4,6,2’,6’-Pentachlorobiphenyl (PCB 104), its Hydroxylated Metabolite 2,4,6,2’,6’-Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2’,4’,6’-Hexachlorobiphenyl (PCB 155)", Environ. Health Persp., 105, 1238-1248 (1997). |
| C. Tashiro, D.W. Potter, B. Sharratt, B. Chittim and Y. Stokker, "HRGC/HRMS Analysis of PCB Congeners: Method Development and Analysis of Reference Materials", Organohalogen Compounds, 23, 273-8 (1995). |
| K. Hu, N.J. Bunce, B.G. Chittim, C.H.M. Tashiro, B.R. Yeo, B.J. Sharratt, F.J. Campbell and D.W. Potter, "Screening Assay for Dioxin-like Compounds Based on Competitive Binding to the Murine Hepatic Ah Receptor. 2. Application to Environmental Samples", Environ. Sci. Technol., 29, 2603-9 (1995). |
| B.G. Chittim, N.J. Bunce, K. Hu, C.H.M. Tashiro and B.R. Yeo, "Comparison of GC-MS With An in vitro Bioassay for PCDDs and Related Compounds in Environmental Samples", Chemosphere, 29, 1783-8 (1994). |
| B.G.Chittim, N.J.Bunce, K.Hu, C.H.M.Tashiro, B.R.Yeo, “Comparison of GC-MS with an in vitro bioassay for PCDDs and related compounds in environmental samples”, Organohalogen Compounds, 11, 5-8, (1993). |
| D. Waddell, J. Sparling, B. Chittim and S. Safe, "Investigation of the Utility of Various Mixed Halogenated Dibenzo-p-Dioxins, Dibenzofurans and Biphenyls as Surrogate/Internal and Injection Standards", Chemosphere, 20, 1299-306 (1990). |
| D.Waddell, B.Chittim, R.Clement, C. Tashiro, S. Davies, A.Szakolcai, P.Steer, T.Dann, “Database of PCDD/PCDF levels in ambient air and in samples related to the pulp and paper industry”, Chemosphere, 20(10-12), 1463-6, (1990). |
| C.Tashiro, R.E.Clement, S. Davies, B.Oliver, T.Munshaw, J.Fenwick, B.Chittim, M.G.Foster, “Water round robin for parts-per-quadrillion determination of PCDDs and PCDFs”, Chemosphere, 20(10-12), 1313-17, (1990). |
| T.Zacharewski, L.Safe, S.Safe, B.Chittim, D.DeVault, K.Wiberg, P.A.Bergqvist, C.Rappe, “Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in vitro enzyme induction activities”, Environmental Science and Technology, 23(6), 730-5, (1989). |
| S.Safe, G.Mason, K.Farrell, B.Keys, J.Piskorska-Pliszczynska, J.A.Madge, B.Chittim, “Validation of in vitro bioassays for 2,3,7,8-TCDD equivalents”, Chemosphere, 16(8-9), 1723-8, (1987). |
| D.S.Waddell, R.K.Boyd, H.S.McKinnon, L.Safe, S.Safe, B.G.Chittim, “Tetrachlorodibenzofurans - gas chromatographic and mass spectrometric characteristics”, Chemosphere, 16(8-9), 1655-60, (1987). |
D.S. Waddell, H.S. McKinnon, B.G. Chittim, S. Safe and R.K. Boyd, "Gas Chromatographic/Mass Spectrometric Characteristics of Purified Synthetic Isomers of Tetrachlorodibenzofuran", Biomed. Environ. Mass Spec., 14, 457-64 (1987).
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B. Chittim, S. Safe and J. Madge, “Pentachlorodibenzofurans: synthesis, capillary gas chromatography and gas chromatographic/mass spectrometric characteristics”, Chemosphere, 15, 1931-4 (1986).
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| B.D.Leece, M.A.Denomme, S.M.A.Li, R.A.Towner, J.W.Gyorkos, B.G.Chittim, S.Safe, “Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships”, Archives of Toxicology, 59(3), 186-9, (1986). |
| O.Hutzinger, G.G.Choudhry, B.G.Chittim, L.E.Johnston, “Formation of polychlorinated dibenzofurans and dioxins during combustion, electrical equipment fires and PCB incineration”, Environmental Health Perspectives, 60 3-9, (1985). |
D.Fung, R.K.Boyd, S.Safe, B.G.Chittim, “Gas chromatographic/mass spectrometric analysis of specific isomers of polychlorodibenzofurans” Biomedical Mass Spectrometry, 12(6), 247-53, (1985).
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L.W. Robertson, B.G. Chittim, S.H. Safe, M.D. Mullin and C.M. Pochine, "Photodecomposition of a Commercial PBB Fire Retardant: High Resolution Gas Chromatographic Analysis", J. Agric. Food Chem. 31, 454-7 (1983).
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| L.W.Robertson, A.Parkinson, B.Chittim, S.Bandiera, T.W.Sawyer, S.Safe, “Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): enhancement by photolysis”, Toxicology, 22(2), 103-14, (1981). |
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Publications
